Gene
Analysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis
Authors: C.L. Ribeiro J�?ºnior, J.T. Arruda, C.T.X. Silva andK.K.V.O. Moura
We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two gro.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr593
- DOI:
- 10.4238/vol8-2gmr593
Biochip analysis of prostate cancer
Authors: M.Q. Fan, P.X. Wang, J.Y. Feng, Y. Xiao and C.B. Huang
Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and their targets can be considered a key factor in determining the differenc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.6
- DOI:
- 10.4238/2014.January.10.6
Use of weaning management group as a random effect for a more robust estimation of genetic parameters for post-weaning traits in Nellore cattle
Authors: V.B. Pedrosa, J.P. Eler, J.B.S. Ferraz and E. Groeneveld
Data from 69,525 animals were used to compare two types of analyses, one of them having the weaning management group (WEMANG) included as an effect in the contemporary group (F_WEMANG) and the other considering the weaning management group as a random effect, not related to the mathematical model (R_WEMANG) for post-weaning tr.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.7
- DOI:
- 10.4238/2014.February.21.7
Treatment of silicosis with hepatocyte growth factor-modified autologous bone marrow stromal cells: a non-randomized study with follow-up
Authors: W.W. Liu, H.X. Wang, W. Yu, X.Y. Bi, J.Y. Chen, L.Z. Chen, L. Ding, D.M. Han, Z.K. Guo and Y.X. Lei
Pulmonary silicosis is an irreversible and untreatable disease that is characterized by interstitial lesions and perpetual fibrosis in the lungs. This study was performed to determine whether mesenchymal stem cells (MSCs) and hepatocyte growth factor (HGF) could exhibit therapeutic effects on human silicosis. This non-randomized uncontrolled trial compris.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.7
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.7
Validation of a reaction volume reduction protocol for analysis of Y chromosome haplotypes targeting DNA databases
Authors: C.A. Souza, T.C. Oliveira, S. Crovella, S.M. Santos, K.C.N. Rab�?ªlo, E.P. Soriano, M.V.D. Carvalho, A.F. Caldas Junior, G.G. Porto, R.I.C. Campello, A.A. Antunes, R.A. Queiroz and S.M. Souza
The use of Y chromosome haplotypes, important for the detection of sexual crimes in forensics, has gained prominence with the use of databases that incorporate these genetic profiles in their system. Here, we optimized and validated an amplification protocol for Y chromosome profile retrieval in reference samples using lesser .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029652
- DOI:
- 10.4238/gmr16029652
Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population
Authors: X.F. Li, Y.X. Chen, W.W. Ye, X.F. Tao, J.H. Zhu, S. Wu and L.Q. Lou
The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.7
- DOI:
- 10.4238/2014.January.10.7
Construction of a lentiviral vector encoding heme oxygenase 1 and its introduction into mouse adipose tissue-derived stem cells
Authors: C.H. Zhu, W. Lei and Z.R. Chen
Many studies exist concerning the use of stem cells as delivery vehicles in gene therapy, expressing genes such as vascular endothelial growth factor 165 and hepatocyte growth factor. However, few reports regarding adipose tissue-derived stem cells (ADSCs) and the heme oxygenase 1 (HO-1) gene have been published. Therefore, we established a lentiviral vec.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.10
Mendelian inheritance, genetic linkage, and genotypic disequilibrium for nine microsatellite loci in Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae)
Authors: T.Y.K. Kubota, A.M. Silva, J. Cambuim, A.A. Silva, S. Pupin, M.S. Silva, M.A. Moraes, M.L.T. Moraes and A.M. Sebbenn
Cariniana estrellensis is one of the largest trees found in Brazilian tropical forests. The species is typical of advanced stages of succession, characteristic of climax forests, and essential in genetic conservation and environmental restoration plans. In this study, we assessed Mendelian inheritance, genetic linkage, and gen.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029653
- DOI:
- 10.4238/gmr16029653
Screening of differentially expressed genes in pathological scar tissues using expression microarray
Authors: L.P. Huang, Z. Mao, L. Zhang, X.X. Liu, C. Huang and Z.S. Jia
Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up- or down-regulated genes in 2-fold differentially expressed genes, 956.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.13
Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis
Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang
Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.16