Authors: �°. G�¶k1, �°. ��elebi2, N. H�¼seyino��lu3 and C. ��zic1
We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral b.. Read More»
Authors: A. Al-Qahtani, S. Alarifi, M. Al-Okail, Z. Hussain4, A. Abdo, F. Sanai, M. Al-Anazi, N. Khalaf, H. Al-Humaidan, M. Al-Ahdal and F.N. Almajhdi
Besides the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. “Regulated on activation normal T-cell expressed and secreted” factor (RANTES) plays a vital role in CD4+, CD8+ T-lymphocyte and dendritic cell activation and proliferati.. Read More»
Authors: A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, L.B. Ferreira, G.S. Lordelo, J.G.M. Melo, C.K. Grisolia, S.F. Oliveira and M.N. Klautau-Guimar�£es
Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigate.. Read More»
Authors: V.S.R. Dukkipati, H.T. Blair, D.J. Garrick and A. Murray
The major histocompatibility complex (MHC) in sheep, Ovar-Mhc, is poorly characterised, when compared to other domestic animals. However, its basic structure is similar to that of other mammals, comprising class I, II and III regions. Currently, there is evidence for the existence of four class I loci. The class II region is b.. Read More»
Authors: F.R. Torres, W.C. Souza-Neiras, A.A. D�Almeida Couto,V.S.C. D�Almeida Couto, C.E. Cavasini, A.R.B. Rossit, R.L.D. Machado and C.R. Bonini-Domingos
Malaria is an endemic parasitosis and its causitive agent, Plasmodium, has a metabolism linked to iron supply. HFE is a gene with the polymorphisms C282Y and H63D, which are associated with a progressive iron accumulation in the organism leading to a disease called hereditary hemochromatosis. The aim of the present study was to determine the allelic and g.. Read More»
Authors: L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length.. Read More»
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. .. Read More»
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% c.. Read More»
Authors: Y. Zhang, N.-F. Li, S. Abulikemu, D.-L. Zhang, Y.-C. Wang, J.-Q. Kong, G.-L. Nuer, Z.-T. Yan, H.-J. Li, J.-H. Zhang and X.-Y. Zhang
Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the.. Read More»