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Gastric Carcinoma

Human Genetics   Research Article

Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation

Authors: Z.F. Xiong, J. Shi, Z.H. Fu, H.P. Wan and L.X. Tu

We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and .. Read More»

Genet. Mol. Res. 16(2):
gmr16029181
DOI:
10.4238/gmr16029181
Animal Genetics   Research Article

Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics

Authors: Y.J. Yang, Z.B. Li, G.R. Zhang, L.J. Wu, J.Y. Yu, L.J. Hu, Y.L. Zhou, H.D. Wang and D. Liang

Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer ste.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038510
DOI:
10.4238/gmr.15038510