Esophageal Squamous Cell Carcinoma
Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population
Authors: H.-P. Yang, J.-F. Liu, J. Rao, X.-M. Zhang, H.-L. Qian, X.-Q. Niu and Z.-L. Zhao
Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcin.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.10
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.10
Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma
Authors: Y. Jang1, S.A. Lu2, Z.P. Chen3, J. Ma3, C.Q. Xu3, C.Z. Zhang3 and J.J. Wang4
Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.2
- DOI:
- 10.4238/2013.December.13.2
Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients
Authors: F. Attaran-Bandarabadi, A.A. Ziaee, M. Yazdanbod, M. Shahpanah, A. Setayeshgar and M. Nassiri
There is a high incidence of esophageal squamous cell carcinoma (ESCC) in Iran. Non-functionality of some tumor suppressor genes has been reported in esophageal cancer. Loss of heterozygosity on chromosome 5 has also been reported in esophageal carcinomas. We assessed loss of heterozygosity along a region of the long arm of ch.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.5.2
- DOI:
- 10.4238/2011.October.5.2
CADM1 mRNA expression and clinicopathological significance in esophageal squamous cell carcinoma tissue
Authors: J.B. Qian, H.B. Liu, Y. Zhu, F. Lu, Q.C. Yang and Y. Shen
The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and st.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029178
- DOI:
- 10.4238/gmr16029178
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer
Authors: L. Zhang, R.-X. Xi and X.-Z. Zhang
We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy co.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.20
- DOI:
- 10.4238/2015.May.4.20
Evaluation of serum HGF and CK18 levels in patients with esophageal cancer
Authors: N. Kilic-Baygutalp, N. Ozturk, E. Orsal-Ibisoglu, B. G�¼ndogdu, F.B. Ozgeris, N. Bakan, E. Bakan and A.F. Kilic
Cytokeratins are thought to play a role in apoptosis. Cytokeratin 18 (CK18) is involved in the formation of intracellular cytoskeleton, and has been considered a promising apoptosis marker in gastrointestinal carcinomas. Growth factors, including hepatocyte growth factor (HGF), may provide a microenvironment for malignant cell.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038583
- DOI:
- 10.4238/gmr.15038583
Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran
Authors: H.A. Marjani, F. Biramijamal, N. Rakhshani, A. Hossein-Nezhad and R. Malekzadeh
We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world. The study included 93 ESCC cases and 50 control individuals who were seen at the clinical .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr693
- DOI:
- 10.4238/vol9-1gmr693
Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma
Authors: G.R. Shen, W.Z. Li, Y.C. Liu, X.P. Li and H.Y. Yuan
MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenet.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028158
- DOI:
- 10.4238/gmr.15028158
Clinical significance of microRNA-34a in esophageal squamous cell carcinoma
Authors: X. Lin, X.Y. Xu, Q.S. Chen and C. Huang
MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P < 0.05), and miR-34a overexpression increased apoptosis and decreased clonogenic formation. However, the clinical significance and prognostic value of miR-34a in ESCC has not yet been investigated. In to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.41
- DOI:
- 10.4238/2015.December.21.41