Endothelin
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population
Authors: Z. Fang, M. Li, Z. Ma and G. Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16037446
- DOI:
- 10.4238/gmr16037446
Comparative study between Ephedra sinica Stapf and Fructus Schisandrae Chinensis on ET-1 and 6-keto-prostaglandin F1�± in rats with idiopathic pulmonary fibrosis
Authors: H.Q. Zhai, J.R. Hhang, M.C. Gao, Y. Liu, S.F. Zhang, X.H. Wang, F.Y. Meng and Y.P. Wang
The aim of this study was to evaluate differences in the effects of Ephedra sinica Stapf and Fructus Schisandrae Chinensis on angiogenesis in the treatment of bleomycin-induced rat idiopathic pulmonary fibrosis. The rat models were created using bleomycin. The animals were divided into six groups: model, control, Ephedra alone.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.13.3
- DOI:
- http://dx.doi.org/10.4238/2014.May.13.3
Effect of Xin Mai Jia on atherosclerosis in rats
Authors: P. Li, G.P. Pan, M. Jia, Q.Q. Wang, Z.G. Guo, F.R. Zhao, G.L. Lei, G.R. Wan and G.M. Wan
We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were established by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheologyrelated indices of blood.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.19
- DOI:
- 10.4238/2015.June.1.19
Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation
Authors: L. He, Y. Sun, Y. Zhu, R. Ren, Y. Zhang and F. Wang
Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiote.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.2
- DOI:
- 10.4238/2014.September.5.2
Active vitamin D3, 1,25-(OH)2D3, protects against macrovasculopathy in a rat model of type 2 diabetes mellitus
Authors: R. Ma, X.L. Deng, G.L. Du, C. Li, S. Xiao, Y. Aibibai and J. Zhu
To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028113
- DOI:
- 10.4238/gmr.15028113