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Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes
Authors: W.R. Bi, C.Q. Yang, Q. Shi, Y. Xu, C.P. Cao, J. Ling and X.Y. Wang
Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.3
- DOI:
- 10.4238/2014.August.7.3
Evaluation of polyvinyl alcohol for fatty acid supplementation in adipose tissue explant culture
Authors: Jose AAFBV, Gama MAS, Urban A, Merighe GK, Meirelles FV, Etchegaray MAL and Lanna DPD
Cultures of adipose tissue explants are a valuable tool for studying the intracellular mechanisms involving hormones and nutrients. However, testing how fatty acids affect cells requires a carrier molecule; bovine serum albumin (BSA) has been used for this purpose. However, contaminants can alter the cellular response. Our obj.. Read More»
- Genet. Mol. Res. 6(1):
Loss of STAG2 causes aneuploidy in normal human bladder cells
Authors: X. Li, T.W. Zhang, J.L. Tang, P.P. Fa, J.X. Lu, F.M. Qi, Z.M. Cai, C.X. Liu and X.J. Sun
The aim of this study was to determine how the function of human stromal antigen 2 (STAG2) plays an important role in proper chromosome separation. STAG2 mRNA in normal bladder cells and bladder tumor cells was evaluated by RT-PCR. The protein levels of STAG2 in normal bladder cells and bladder tumor cells were determined by western blot. A cell prolifera.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.24
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.24
Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective
Authors: Y. Huang, L. Wang, B. Bennett, R.W. Williams, Y.J. Wang, W.K. Gu and Y. Jiao
The mitochondrial ATP synthase, subunit c, isoform 3 gene (Atp5g3) encodes subunit 9, the subunit of the multisubunit enzyme that catalyzes ATP synthesis during oxidative phosphorylation in mitochondria. According to the Ensembl database, Atp5g3 in mice is located on chromosome 2 between 73746504 and 73749383 bp, within the genomic regions of two sets of .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.18.1
- DOI:
- 10.4238/2013.September.18.1
Protective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys
Authors: W.Z. Li, X.H. Wang, H.X. Zhang, S.M. Mao and C.Z. Zhao
The objective of this study was to observe the protective effect of the n-butyl alcohol phase of Toona sinensis seed extract on the kidneys of diabetic nephropathy (DN) rats and its preliminary mechanism. Male wistar rats were administered a normal or high-fat diet for 1 month. DN rats were divided into a model group and a pet.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017403
- DOI:
- 10.4238/gmr.15017403
Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study
Authors: F. Xiong,Y. Tong,P. Li,T. Huo and M. Mao
We evaluated the relationship between total serum immunoglobulin E (IgE) levels and pregnancy outcome in a prospective cohort study focusing on fetal growth restriction (FGR). Sixty women with FGR and twenty with normal singleton pregnancy were enrolled during their third trimester. Infants were followed up for 6 months. Blood samples were obtained from p.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.2
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer
Authors: M.A. Proen�§a, G.M.M. Fernandes, A. Russo, R.B. Lelis, J.G. Netinho, G.S. Cunrath, A.E. Silva, E.M. Goloni-Bertollo and E.C. Pavarino
Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. We.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.10
- DOI:
- 10.4238/2015.December.22.10
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis
Authors: L.L. Zhang, Y.Q. Wang, B. Fu, S.L. Zhao and Y. Kui
We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.38
- DOI:
- 10.4238/2015.December.23.38
Micronucleus investigation of alcoholic patients with oral carcinomas
Authors: Andr�©a Ramirez, Pedro Henrique Saldanha
The micronucleus test (MN) is used as an indicator of genotoxic exposition, since it is associated with chromosome aberrations. An increased mutation rate in oral squamous cells, indicated by an increased MN frequency, is also related to the development of oral carcinomas. We evaluated the frequencies of MN and other metanucle.. Read More»
- Genet. Mol. Res. 1(3):