Cancer
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25
Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis
Authors: M.L. Zhi, Z.J. Liu, X.Y. Yi, L.J. Zhang and Y.X. Bao
Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.28
- DOI:
- 10.4238/2015.December.22.28
High expression of HIF-2�± and its anti-radiotherapy effect in lung cancer stem cells
Authors: J.C. Sun, F. He, W. Yi, M.H. Wan, R. Li, X. Wei, R. Wu and D.L. Niu
Hypoxia-inducible factor-2 alpha (HIF-2α) has been shown to regulate cell stemness, although the expression and effects of HIF-2α in lung cancer stem cells remained unclear. This study investigated HIF-2α expression in lung cancer stem cells, as well as the relationship between HIF-2α expression and radioresistance in lung cancer c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.37
- DOI:
- 10.4238/2015.December.22.37
Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer
Authors: D.L. Yang, M.M. Xin, J.S. Wang, H.Y. Xu, Q. Huo, Z.R. Tang and H.F. Wang
It is well known that chemokine receptors and their ligands play important roles in mediating the invasion and metastasis of malignant tumors. This aim of this study was to investigate the expression and clinical significance of chemokine receptor CXCR4 and its ligand CXCL12 in bladder tumor tissues. Cancerous and adjacent normal bladder tissues were coll.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.43
- DOI:
- 10.4238/2015.December.21.43
Pooled analysis of association between a genetic variant in the 3'-untranslated region of Toll-like receptor 4 and cancer risk
Authors: X. Wang, Z. Xu and C.H. Miao
Many epidemiological studies have shown the association between certain genetic variations in the Toll-like receptor 4 (TLR4) gene (for example, rs4986790 and rs4986791) and cancer risk. However, the results from investigations into the association between rs11536889, a genetic variant in the 3'-untranslated region of TLR4, and cancer risk lack consensus... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.9
- DOI:
- 10.4238/2015.December.22.9
Effect of lipoic acid combined with paclitaxel on breast cancer cells
Authors: B.J. Li, X.Y. Hao, G.H. Ren and Y. Gong
Breast cancer is the most common gynecologic tumor globally that threatens women’s health. Lipoic acid is a type of antioxidant that can alleviate oxidative stress damage. Studies showed that lipoic acid could inhibit the proliferation of tumor cells in cervical cancer and colon cancer. This paper intends to explore the combined effect of lipoic aci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.18
- DOI:
- 10.4238/2015.December.22.18
Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer
Authors: Y.B. Ma, G.X. Li, J.X. Hu, X. Liu and B.M. Shi
MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase cha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.2
- DOI:
- 10.4238/2015.December.23.2
Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer
Authors: D.K. Sun, L. Wang, J.M. Wang and P. Zhang
Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 exp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.5
- DOI:
- 10.4238/2015.December.23.5
Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer
Authors: Z.Y. Pan, Z.S. Jiang and H.Q. Ouyang
We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.14
- DOI:
- 10.4238/2015.August.19.14
Evaluation of novel assays for the detection of human papilloma virus in self-collected samples for cervical cancer screening
Authors: Q. Chen, H. Du, R. Zhang, J.H. Zhao, Q.C. Hu, C. Wang, G.X. Wang, J.L. Tang and R.F. Wu
The aim of this study was to evaluate the performance of three new high-risk human papillomavirus (HPV) assays for primary cervical cancer screening, by using self-collected samples, and to identify an HPV assay that could overcome the major obstacles faced during large-scale population-based screening. Two hundred and ten wom.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027896
- DOI:
- 10.4238/gmr.15027896