Cancer
Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy
Authors: X.-L. Xu, Y.-L. Yao, W.-Z. Xu, J.-G. Feng and W.-M. Mao
Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with respo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.16
Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients
Authors: H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao
We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restrictio.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.3
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women
Authors: L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.15
- DOI:
- 10.4238/2015.July.28.15
Expression and antibody generation of the cancer-testis antigen, BIOT2-S
Authors: J.-Y. Wang, M. Cao, M.-R. Guo, S. Li, X.-F. Yang, M. Wang, J. Fang and J. Zhao
Biot2-S is a mouse cancer-testis antigen gene that was identified using the cross-reactive serological analysis of recombinant cDNA expression libraries (SEREX) technique in the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. To express BIOT2-S and generate its antibody for further investigation, the Biot2-S prokaryotic recomb.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.17
- DOI:
- 10.4238/2015.July.31.17
Impact of enteral nutrition on postoperative immune function and nutritional status
Authors: F. Wang, M.X. Hou, X.L. Wu, L.D. Bao and P.D. Dong
We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surger.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.4
- DOI:
- 10.4238/2015.June.8.4
Adjuvant chemotherapy may improve survival of patients with luminal A breast cancer and positive lymph nodes
Authors: Y. Han, Q. Li, B.H. Xu, P. Zhang, P. Yuan, J.Y. Wang, F. Ma, R.G. Cai and Y. Fan
The study examined the clinicopathological characteristics and treatment options in patients with luminal A breast cancer. This retrospective cohort included 1580 patients with luminal A breast cancer treated between January 2005 and June 2007. Patients were divided into four subgroups according to lymph node status. Prognostic factors and 5-year overall .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.4
- DOI:
- 10.4238/2015.July.31.4
Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis
Authors: Z.F. Chen, L.L. Ma and H.B. Xue
The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The lit.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.7
- DOI:
- 10.4238/2015.July.31.7
BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer
Authors: N. VelÃ?¡zquez-HernÃ?¡ndez, M.A. Reyes-Romero, M. BarragÃ?¡n-HernÃ?¡ndez, F. Guerrero-Romero, M. RodrÃ?Âguez-Moran, M. Aguilar-DurÃ?¡n and B. Lazalde Medina
We investigated the expression of Brother of Regulator of Imprinted Sites (BORIS) and CCCTC-binding factor (CTCF) in squamous intraepithelial lesions and cervical cancer. To analyze BORIS and CTCF expression, an endocervical cytobrush sample was taken for total RNA isolation. CTCF and BORIS mRNA was quantified from total RNA using quantitative reverse tra.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.7
- DOI:
- 10.4238/2015.June.8.7
Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma
Authors: Y.T. Zou, J.Y. Gao, H.L. Wang, Y. Wang, H. Wang and P.L. Li
MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21-23 nt long) that can target genes for either degradation of mRNA or inhibition of translation. miRNAs have not been comprehensively studied in human epithelial ovarian carcinoma (EOC). MicroRNA-630 (miR-630) has been frequently observed to be aberrantly expressed in various types o.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.25
- DOI:
- 10.4238/2015.July.31.25
Association between interleukin-17 gene polymorphisms and the risk of laryngeal cancer in a Chinese population
Authors: F.Z. Si, Y.Q. Feng and M. Han
IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019076
- DOI:
- 10.4238/gmr16019076