Acute Myeloid Leukemia
Association of GSTTI and GSTM1 variants with acute myeloid leukemia risk
Authors: Y.M. Zi, S. Wu, D. Ma, C. Yang, M. Yang, Y. Huang and S.J. Yang
We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the du.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.9.11
- DOI:
- http://dx.doi.org/10.4238/2014.May.9.11
Prognostic implication of molecular aberrations in cytogenetically normal acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation
Authors: Y.C. Liu1,2,3*, H.H. Hsiao1,2*, P.M. Lin4, W.C. Yang1,3, C.S. Chang1,2, T.C. Liu1,3, J.F. Hsu1, M.Y. Yang5 and S.F. Lin1,2
Different molecular aberrations can be discriminated into certain prognostic subgroups in cytogenetically normal acute myeloid leukemia (CN-AML) patients but their impact on allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial and studies from Asian populations are lacking. Forty-two adult non-M3 AML patients receiving allo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.11.3
- DOI:
- 10.4238/2013.November.11.3
Biological activity of cytotoxic dendritic cells cocultured with cytokine-induced killer cells and their effect on acute leukemia cells
Authors: X.Y. Cheng and J.L. Li
We cocultured cytokine-induced killer (CIK) cells with dendritic cells (DCs) in vitro and investigated their proliferation, immunophenotype changes, secretory cytokine levels, and their antitumor effects on acute myeloid leukemia (AML) cells. DCs and CIK cells were acquired from healthy human peripheral blood mononuclear cells and cocultured as an experim.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.17
- DOI:
- 10.4238/2015.October.26.17
Serum proteomic spectral characteristics of acute myeloid leukemia and their clinical significance
Authors: R.-J. Zheng, R.-J. Wu and X.-D. Ma
We investigated the differences between the serum proteomic spectral characteristics of acute myeloid leukemia (AML) patients and those of healthy people. We collected peripheral blood serum samples from 62 AML patients and 15 healthy controls. After removing high-abundance proteins, low-abundance serum proteins were separated.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029172
- DOI:
- 10.4238/gmr16029172
Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia
Authors: C. Fei, X.M. Yao, Y. Sun, X.Z. Gu, L.Q. Yu and X. Lai
We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.15
- DOI:
- 10.4238/2015.February.2.15
Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients
Authors: Y.Z. Su, C.B. Wang, Y. Zhou and N.T. Sun
The present study aimed to explore the changes in serum endostatin and fibroblast growth factor 19 (FGF-19) in acute myeloid leukemia patients, and to determine their effects on chemotherapeutic sensitivity. Sixty acute myeloid leukemia patients and 30 healthy controls were included in the study. Patient serum endostatin and FGF-19 levels were measured on.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.8
- DOI:
- 10.4238/2015.May.18.8
135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis
Authors: L. Wu, Z.G. Long and Z.S. Dai
Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027383
- DOI:
- 10.4238/gmr.15027383
Additional chromosomal abnormalities in core-binding factor acute myeloid leukemia
Authors: H.H. Hsiao, Y.C. Liu, H.C. Wang, Y.F. Tsai, C.H. Wu, S.F. Cho, J.F. Hsu, C.T. Huang, S.Y. Hsiao, C.P. Lee, C.S. Chang, S.F. Lin and T.C. Liu
Despite sharing a similar genetic abnormality, patients with core binding factor acute myeloid leukemia (CBF-AML), which is characterized by the presence of t(8;21) or inv(16)/t(16;16), show heterogeneous survival. Other molecular or cytogenetic factors are supposed to have an impact on the prognosis. We enrolled 24 CBF-AML patients to determine the impac.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.3
- DOI:
- 10.4238/2015.December.16.3