Investigation of clinical diagnosis and liver biopsy diagnosis in cases of patients with chronic HBV infection
Authors: W.-Q. Shi, W. Ni and Y.-L. Yang
The aim of this study was to investigate the pathomorphological changes of chronic hepatitis B virus (HBV) infection and the coincidence between clinical and pathological diagnosis. Hematoxylin and eosin staining and immunohistochemistry for HBsAg and HBcAg were performed on 97 liver biopsy specimens collected from 97 patients.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.13.16
- DOI:
- 10.4238/2014.February.13.16
An oleosin-fusion protein driven by the CaMV35S promoter is accumulated in Arabidopsis (Brassicaceae) seeds and correctly targeted to oil bodies
Authors: W. Li, L.G. Li, X.F. Sun1and K.X. Tang
Oleosin-fusion technology is used to express desired proteins. It was developed based on the properties of oleosin; the heterologous protein gene is fused to the oleosin gene and the fusion gene is driven by a seed-specific promoter. We replaced the seed specific promoter with the CaMV35S promoter to dive a gfp-oleosin fusion gene in transformed Arabidops.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.1
- DOI:
- 10.4238/2012.August.13.1
High resolution computed tomography and classification of children with interstitial lung diseases
Authors: M.L. He, H. Lai, Y. Cao, Y.Z. Shuai and S.C. Yu
High resolution computed tomography (HRCT) was used to classify children with interstitial lung diseases (ILD). Sixty children with ILD underwent HRCT in supine position under free-respiratory conditions during scanning. Children under 5 years old were sedated with chloral hydrate and the scanning scope was from the lung apex .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.9
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.9
Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma
Authors: Y. Jang1, S.A. Lu2, Z.P. Chen3, J. Ma3, C.Q. Xu3, C.Z. Zhang3 and J.J. Wang4
Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.2
- DOI:
- 10.4238/2013.December.13.2
Complete sequence analysis of mitochondrial DNA of aplastic anemia patients
Authors: X. Cui, F. Liu, J.Q. Wang, W.J. Zhang, J.Y. Wang, K. Liu, S.Y. Cui, J. Zhang and R.R. Xu
This study was primarily undertaken to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia (AA). We analyzed mtDNA sequences from 15 patients with AA. The samples were obtained from bone marrow, and patients’ oral epithelial cells were collected for normal tissue comparison. Total DNA was amplified by .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.16
- DOI:
- 10.4238/2012.August.6.16
Correlation and interventional embolization therapy of posterior intercostal arteries-induced hemoptysis
Authors: Y.P. Chen, Y.G. Chen, F. Jiang and J.M. Chen
The incidence of posterior intercostal arteries-induced hemoptysis, its correlation with primary diseases, and the value of interventional embolization therapy were investigated. Clinical data, multislice spiral computed tomography (MSCT), digital subtraction angiography (DSA), and other imaging data of 143 cases of hemoptysis.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.10
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.10
Gene expression and molecular modeling of the HSP104 chaperone of Trypanosoma cruzi
Authors: R.A. Campos, M.L. da Silva, G.V. da Costa, P.M. Bisch, J.M. Peralta, R. Silva, E. Rondinelli and T.P. ��rm�©nyi
Heat shock protein (HSP) 104 is a highly conserved molecular chaperone that catalyzes protein unfolding, disaggregation and degradation under stress conditions. We characterized HSP104 gene structure and expression in Trypanosoma cruzi, a protozoan parasite that causes Chagas’ disease. The T. cruzi HSP104 is an 869 amino-acid protein encoded by a si.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.15
- DOI:
- 10.4238/2012.August.6.15
Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome
Authors: X.H. Wang, S.Q. Liu, Y.L. Wang and Y. Jin
Serum high-sensitivity C-reactive protein (hs-CRP) is a sensitive indicator of inflammation, which is closely related with the progress of plaque formation. Interleukin-6 (IL-6) is one of the inflammatory markers of local coronary plaque and the peripheral blood cycle, promoting the occurrence of atherosclerosis development an.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.11
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.11
Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru
Authors: M. Martorell, J.A. Garcia-Garcia, D. Gomez-Cabrero, A. del Aguila
We made a study of the prevalence of human papillomavirus (HPV) and cervix lesions in an Amazonian Bora native population (Bn) and compared it with the prevalence in an urban population in Iquitos (Iq). We also examined the distribution of HPV types among abnormal cervical smears in the Iq population. Swabs and cytologies were collected from 472 females. .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.14
- DOI:
- 10.4238/2012.August.6.14
Thirty-four Musa (Musaceae) expressed sequence tag-derived microsatellite markers transferred to Musella lasiocarpa
Authors: W.J. Li, H. Ma, Z.H. Li, Y.M. Wan, X.X. Liu and C.L. Zhou
We assembled 31,308 publicly available Musa EST sequences into 21,129 unigenes; 4944 of them contained 5416 SSR motifs. In all, 238 unigenes flanking SSRs were randomly selected for primer design and then tested for amplification in Musella lasiocarpa. Seventy-eight primer pairs were found to be transferable to this species, and 49 displayed polymorphism... Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.13
- DOI:
- 10.4238/2012.August.6.13