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Human Genetics   Research Article

Shortening of the cell cycle and developmental interruption in a Dictyostelium discoideum cell line due to RNAi-silenced expression of allantoicase

Authors: D.M. Xue and L.S. Hou

The signaling molecules NH3 (unprotonated volatile ammonia), as well as cyclic adenosine monophosphate and differentiationinducing factor, play important roles in the multicellular development of the slime mould Dictyostelium discoideum. One of the downstream metabolic products catalyzed by allantoicase (allC) is ammonia. We o.. Read More»

Genet. Mol. Res. 11(3):
2012.July.19.11
DOI:
10.4238/2012.July.19.11
Human Genetics   Research Article

Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation

Authors: C.R. Quaio, Y.K. Koda, D.R. Bertola, M. Sukalo, M. Zenker and C.A. Kim

Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive disorder resulting from loss-of-function mutations in the UBR1 gene. JBS can be easily recognized by its unique clinical presentation (including exocrine pancreatic insufficiency, hypoplasia/aplasia of the alae nasi, congenital scalp defects, sensorineural hearing .. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.June.9.2
DOI:
http://dx.doi.org/10.4238/2014.June.9.2
Bioinformatics   Research Article

FastJoin, an improved neighbor-joining algorithm

Authors: J. Wang, M.-Z. Guo and L.L. Xing

Reconstructing the evolutionary history of a set of species is an elementary problem in biology, and methods for solving this problem are evaluated based on two characteristics: accuracy and efficiency. Neighbor-joining reconstructs phylogenetic trees by iteratively picking a pair of nodes to merge as a new node until only one.. Read More»

Genet. Mol. Res. 11(3):
2012.July.19.10
DOI:
10.4238/2012.July.19.10
Human Genetics   Research Article

Protein transduction domain-hA20 fusion protein protects endothelial cells against high glucose-induced injury

Authors: C.L. Hou, Q. Huang, Y. Wei, W. Zhang, J.H. Mi, D.J. Ying and Z.H. Zhou

We constructed a plasmid containing a protein transduction domain (PTD) and a human A20 (hA20) gene fragment; the fusion protein was obtained by highly expressing this plasmid in the yeast Pichia pastoris GS115. The plasmid was obtained by adding 9xArg and EcoRÐÂ? recognition sites to the end of the primer, and 6xHis-Tag and .. Read More»

Genet. Mol. Res. 11(3):
2012.July.19.9
DOI:
10.4238/2012.July.19.9
Human Genetics   Research Article

Cytogenetic studies on meiotic chromosome behaviors in sterile Oriental x Trumpet lily

Authors: J.R. Luo, J.M. Van Tuyl, P. Arens and L.X. Niu

In order to determine the reasons for pollen sterility in lily hybrids, four diploid sterile Oriental x Trumpet (OT) lily cultivars (‘Nymph’, ‘Gluhwein’, ‘Yelloween’, and ‘Shocking’) were used to investigate the meiotic chromosome behaviors in pollen mother cells (PMCs), using genomic in situ hybridization a.. Read More»

Genet. Mol. Res. 12(4):
2013.December.13.1
DOI:
10.4238/2013.December.13.1
Microbial Genetics   Research Article

New support vector machine-based method for microRNA target prediction

Authors: L. Li, Q. Gao, X. Mao and Y. Cao

MicroRNA (miRNA) plays important roles in cell differentiation, proliferation, growth, mobility, and apoptosis. An accurate list of precise target genes is necessary in order to fully understand the importance of miRNAs in animal development and disease. Several computational methods have been proposed for miRNA target-gene id.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.June.9.3
DOI:
http://dx.doi.org/10.4238/2014.June.9.3
Plant Genetics   Research Article

Genetic relationships of Pacific abalone (Haliotidae) species determined using universal rice primer-polymerase chain reaction fingerprinting

Authors: H.S. An, J.Y. Park, J.I. Myeong and C.M. An

Random amplified polymorphic DNA (RAPD) with universal rice primers (URP) was used to identify species and to determine phylogenetic relationships for the 6 economically important Korean Pacific abalone species: Haliotis discus hannai, H. discus discus, H. madaka, H. gigantea, H. diversicolor supertexta, and H. diversicolor diversicolor, whose morphologic.. Read More»

Genet. Mol. Res. 12(4):
2013.December.4.18
DOI:
10.4238/2013.December.4.18
Plant Genetics   Research Article

Age-related changes in the surface pheromones of the wasp Mischocyttarus consimilis (Hymenoptera: Vespidae)

Authors: E.F. Neves, L.H.C. Andrade, Y.R. SĂ?Âșarez, S.M. Lima and W.F. Antonialli-Junior

One of the most important attributes that allowed the evolution and maintenance of sociality in insects is their ability to distinguish members of their own colonies. The capacity for individual recognition in social insects is mediated by chemical signals that are acquired soon after the adult emerges, and vary according to t.. Read More»

Genet. Mol. Res. 11(3):
2012.July.19.8
DOI:
10.4238/2012.July.19.8
Human Genetics   Research Article

Autogenous radiocephalic hemodialysis access in patients with small caliber cephalic veins after expansion with a Fogarty catheter

Authors: X. Li, L.H. Fan, J.J. Liu and D.C. Xu

Autogenous arteriovenous fistula (AVF) is the first choice for hemodialysis access in renal failure with uremia. However, AVF cannot be performed in some patients due to small and narrow veins in the forearm. In this study, a Fogarty catheter was used to establish autogenous radiocephalic hemodialysis access in patients with small caliber cephalic veins, .. Read More»

Genet. Mol. Res. 13(3):
2014.February.25.3
DOI:
10.4238/2014.February.25.3
Medical Genetics   Research Article

In silico modeling of the Moniliophthora perniciosa Atg8 protein

Authors: A.C.F. Pereira, T.H.S. Cardoso, M. Brendel and C. Pungartnik

Autophagy is defined as an intracellular system of lysosomal degradation in eukaryotic cells, and the genes involved in this process are conserved from yeast to humans. Among these genes, ATG8 encodes a ubiquitin-like protein that is conjugated to a phosphatidylethanolamine (PE) membrane by the ubiquitination system. The Atg8p-PE complex is important in i.. Read More»

Genet. Mol. Res. 12(4):
2013.December.11.13
DOI:
10.4238/2013.December.11.13