Structure of mitochondrial DNA control region and genetic diversity of Moschus berezovskii populations in Shaanxi Province
Authors: H. Feng, C.L. Feng, Y. Huang and J. Tang
In China, Moschus berezovskii (forest musk deer), a first-class national protected animal, was earlier widely distributed. However, wild populations of the forest musk deer have declined because of human activity and habitat loss. In order to gather useful information for its conservation and management, we investigated the ge.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027578
- DOI:
- 10.4238/gmr.15027578
MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation
Authors: Y. Yang, L.J. Yang, M.Z. Deng, Y.Y. Luo, S. Wu, L. Xiong, D. Wang,Y. Liu and H. Liu
Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochra.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027615
- DOI:
- 10.4238/gmr.15027615
Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer
Authors: L. Liu, T. Meng, Q.S. Wang, H.Z. Jin, Z.Q. Sun, B. Jin, F. Fang and H.J. Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance o.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027704
- DOI:
- 10.4238/gmr.15027704
Comparative analysis of protocols for DNA extraction from soybean caterpillars
Authors: J. Palma, I. Valmorbida, I.F.D. da Costa and J.V.C. Guedes
Genomic DNA extraction is crucial for molecular research, including diagnostic and genome characterization of different organisms. The aim of this study was to comparatively analyze protocols of DNA extraction based on cell lysis by sarcosyl, cetyltrimethylammonium bromide, and sodium dodecyl sulfate, and to determine the most.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027904
- DOI:
- 10.4238/gmr.15027904
Analysis of �±1 and �±2 globin genes among patients with hemoglobin Adana in Malaysia
Authors: T.Y. Lee, M.I. Lai, P. Ismail, V. Ramachandran, J.A.M.A. Tan, L.K. Teh,R. Othman, N.H. Hussein and E. George
Hemoglobin (Hb) Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a non-deletional α-thalassemia variant found in Malaysia. An improvement in the molecular techniques in recent years has made identification of Hb Adana much easier. For this study, a total of 26 Hb Adana α-thalassemia intermedia and 10 Hb Adana trai.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027400
- DOI:
- 10.4238/gmr.15027400
NF1 frameshift mutation (c.6520_6523delGAGA) association with nervous system tumors and bone abnormalities in a Chinese patient with neurofibromatosis type 1
Authors: S.Y. Su, X. Zhou, X.M. Pang, C.Y. Chen, S.H. Li and J.L. Liu
Neurofibromatosis type 1, also known as NF1 or von Recklinghausen’s disease, is a common neurocutaneous syndrome that presents with multiple café-au-lait patches, skinfold freckling, dermatofibromas, neurofibromas, and Lisch nodules. The mutations of the gene NF1, encoding the protein neurofibromin, have been iden.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027572
- DOI:
- 10.4238/gmr.15027572
MMP-9 genetic polymorphism may confer susceptibility to COPD
Authors: S. Jiang, Z.H. Yang, Y.Y. Chen, Z. He, Y. Zhou, Y. Gao, Q. Zhang and M.Q. Tan
Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to con.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026272
- DOI:
- 10.4238/gmr.15026272
Description of the diploid chromosome set of Triatoma pintodiasi (Hemiptera, Triatominae)
Authors: K.C.C. Alevi, F.F.F. Moreira, J. Jurberg and M.T.V. Azeredo-Oliveira
Triatoma pintodiasi has been described and recently grouped in the Rubrovaria subcomplex. T. pintodiasi was initially compared to T. carcavalloi by staining and subsequently identified as T. circummaculata. However, after thorough examination, it was observed to be a cryptic species of T. circummaculata, and was described base.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026343
- DOI:
- 10.4238/gmr.15026343
Characterization of grass carp spleen transcriptome during GCRV infection
Authors: B.H. Xu, L. Zhong, Q.L. Liu, T.Y. Xiao, J.M. Su, K.J. Chen, H.Q. Wang, Y.J. Dai and J. Chen
The aim of the study was to investigate the grass carp hemorrhagic infection pathway and its key-related genes. Grass carp reovirus (GCRV) might cause hemorrhagic disease in grass carps. Healthy grass carp fingerlings (N = 60) were divided into control and infected groups. Fish in the control group were intraperitoneally (ip) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026650
- DOI:
- 10.4238/gmr.15026650
Prediction efficiency of PITX2 DNA methylation for prostate cancer survival
Authors: Z.M. Luan, H. Zhang and X.L. Qu
This study determined the level of PITX2 methylation in prostate cancer and benign tissues and its relationship with the postoperative survival rate. Forty-four patients with prostate cancer who underwent radical prostatectomy and 43 patients with benign prostatic hyperplasia were selected. DNA was extracted from the tissues a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026750
- DOI:
- 10.4238/gmr.15026750