Changes in gene expression and catalase activity in Oryza sativa L. under abiotic stress
Authors: I.L. Vighi, L.C. Benitez, M.N. do Amaral, P.A. Auler, G.P. Moraes, G.S. Rodrigues, L.C. da Maia, L.S. Pinto and E.J.B. Braga
Different rice (Oryza sativa L.) genotypes were subjected to high salinity and low temperature (150 mM NaCl and 13°C, respectively) for 0, 6, 24, 48, or 72 h. We evaluated the simultaneous expression of the genes OsCATA, OsCATB, and OsCATC, correlated gene expression with enzyme activity, and verified the regulation of the.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048977
- DOI:
- 10.4238/gmr15048977
Role of IL-8 gene polymorphisms in glioma development in a Chinese population
Authors: J.W. Fu, K.W. Wang and S.T. Qi
This case-control study aimed to investigate the role of -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms in the interleukin-8 (IL-8) gene in the development of glioma in a Chinese population. One hundred and twenty-seven glioma patients and 284 healthy control subjects were recruited to this study between February 2013 and December 2014. Th.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038127
- DOI:
- 10.4238/gmr.15038127
Association between a non-synonymous HSD17B4 single nucleotide polymorphism and meat-quality traits in Berkshire pigs
Authors: J.L. Jo, J.H. Hwang, S.G. Kwon, D.H. Park, T.W. Kim, D.G. Kang, G.E. Yu, I.S. Kim, J. Ha and C.W. Kim
Single nucleotide polymorphisms (SNPs) are useful genetic markers that allow correlation of genetic sequences with phenotypic traits. It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during β-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:12.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048970
- DOI:
- 10.4238/gmr15048970
Genetic ACE I/D and ACTN3 R577X polymorphisms and adolescent idiopathic scoliosis
Authors: R.P. Luciano, M. Wajchenberg, S.S. Almeida, C.E.N. Amorim, L.M.R. Rodrigues, R.C. Araujo, E.B. Puertas and F. Faloppa
The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and &alph.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048959
- DOI:
- 10.4238/gmr15048959
Development of RAPD-SCAR markers for different Ganoderma species authentication by improved RAPD amplification and molecular cloning
Authors: J.J. Fu, M.A. Khan, Z.Q. Mei, M. Tania, L.Q. Yang and J.L. Cheng
The sequence-characterized amplified region (SCAR) is a valuable molecular technique for the genetic identification of any species. This method is mainly derived from the molecular cloning of the amplified DNA fragments achieved from the random amplified polymorphic DNA (RAPD). In this study, we collected DNA from 10 species of Ganoderma mushroom and ampl.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.19
- DOI:
- 10.4238/2015.May.25.19
Histone H3K9 acetylation influences growth characteristics of goat adipose-derived stem cells in vitro
Authors: X. Wang, F.X. Zhang, Z.M. Wang, Q. Wang, H.F. Wang, Y. Ren,D.P. Tai, H. Liang and D.J. Liu
Adipose-derived stem cells (ADSCs) show nearly unlimited potential in medical and animal science. Currently, understanding of the biological mechanisms regulating ADSC growth in vitro remains very limited. Histone acetylation, an epigenetic modification, plays a key role in maintaining stem cell properties. To further study it.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048954
- DOI:
- 10.4238/gmr15048954
Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis
Authors: Y.W. Pan, Z.G. Zhou, M. Wang, J.Q. Dong, K.P. Du, S. Li, Y.L. Liu, P.J. Lv and J.B. Gao
Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048949
- DOI:
- 10.4238/gmr15048949
Identifying potential PARIS homologs in D. melanogaster
Authors: E.M. Merzetti and B.E. Staveley
Mitochondrial destruction leads to the formation of reactive oxygen species, increases cellular stress, causes apoptotic cell death, and involves a cascade of proteins including PARKIN, PINK1, and Mitofusin2. Mitochondrial biogenesis pathways depend upon the activity of the protein PGC-1α. These two processes are coordin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048934
- DOI:
- 10.4238/gmr15048934
Male idiopathic infertility and the TP53 polymorphism in codon 72
Authors: M.P. de Morais, R.F. Curado, K.S.F. e Silva, K.K.V.O. Moura and J.T. Arruda
Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes sugges.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048882
- DOI:
- 10.4238/gmr15048882
Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children
Authors: L. Li, Y. Li, X.C. Zeng, J. Li and X.Y. Du
Asthma is an allergic disease characterized by hyperresponsiveness and chronic inflammation of the airway. The interleukin-4 (IL-4) gene and its single nucleotide polymorphisms are associated with asthma susceptibility in children. A case-control study was performed to evaluate the relationship between asthma risk and the IL-4.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048873
- DOI:
- 10.4238/gmr15048873