Involvement of ERK1/2 signaling in proliferation of eight liver cell types during hepatic regeneration in rats
Authors: X.G. Chen C.S. Xu Y.M. Liu
It has been well established that ERK1/2 signaling, often subdivided into nine types of pathways, can regulate the hepatocyte proliferative response during liver regeneration. However, the effect of ERK1/2 signaling on the proliferation of other hepatic cell types remains unclear. We isolated and purified 8 liver cell types at 10 time points after 2/3 hep.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.11.14
- DOI:
- 10.4238/2013.March.11.14
A novel COL7A1 mutation in a Korean patient with Hallopeau-Siemens recessive dystrophic epidermolysis bullosa
Authors: J. Park H. Chae M. Kim Y. Kim I.Y. Park J.C. Shin Y.M. Park
Dystrophic epidermolysis bullosa (DEB) is an inherited skin fragility disorder that presents various clinical manifestations. DEB is characterized by separation of sublamina densa tissue and abnormalities in the anchoring fibrils that result from mutations in COL7A1 and subsequent defects in type VII collagen. A 16-month-old boy was diagnosed with Hallopeau-.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.11.15
- DOI:
- 10.4238/2013.March.11.15
Meiosis, spermatogenesis and nucleolar behavior in the seminiferous tubules of Alydidae, Coreidae and Rhopalidae (Heteroptera) species
Authors: H.V. Souza, F.B. Souza, S.R.C. Maruyama, M.M.U. Castanhole andM.M. Itoyama
We studied the karyotype, spermatogenesis and nucleolar activity at spermatogenesis in five species of Heteropera: Hyalymenus sp and Neomegalotomus pallescens, Alydidae; Catorhintha guttula and Hypselonotus fulvus, Coreidae; and Niesthrea sidae, Rhopalidae. They showed a red (Alydidae) or orange (Coreidae and Rhopalidae) membr.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr672
- DOI:
- 10.4238/vol8-4gmr672
Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-1 cells
Authors: D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.18
- DOI:
- 10.4238/2015.January.15.18
Molecular cytogenetic characterization of the Aegilops biuncialis karyotype
Authors: J. Wang W. Zhang H. Zhao F.R. Li Z.G. Wang J. Ji X.Q. Zhang D.W. Wang J.M. Li
Aegilops biuncialis can be hybridized with wheat (Triticum spp) and has been used for wheat breeding and genetic studies. The A. biuncialis karyotype (Ub Ub Mb Mb) was investigated based on three A. biuncialis accessions grown in China. Two pairs of SAT chromosomes were identified as 1Ub and 5Ub, with a karyotype formula of 2n = 4x = 28 = 14m + 10sm + 4st. F.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.11.16
- DOI:
- 10.4238/2013.March.11.16
Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain injury
Authors: R. Zhang1, Z.Y. Wang1, L.L. Zhu1, F. Wu1, D.Q. Chen1, L.F. Sun1 and Z.Q. Lu2
Resistin (RSTN) expression in subcutaneous adipose tissue, and its effect on glucose metabolism in rats with traumatic brain injury, was investigated using real-time PCR, western blots, and enzyme linked immunoassays. Our results show that the expression of RSTN mRNA (3.192 ± 0.046, 4.016 ± 0.010, 6.004 ± 0.020, 8.213 ± 0.013, .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017659
- DOI:
- 10.4238/gmr.15017659
Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis
Authors: Y. Liu, X.L. Song, G.L. Zhang, A.M. Peng, P.F. Fu, P. Li, M. Tan, X. Li, M. Li and C.H. Wang
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.19
- DOI:
- 10.4238/2015.January.15.19
Array-CGH analysis in patients with intellectual disability and/or congenital malformations in Brazil
Authors: G.S. Vianna1, P.F.V. Medeiros2, A.F. Alves2, T.O. Silva2 and F.S. Jehee1
In several patients, intellectual disability and/or congenital malformation may be attributed to chromosomal changes. In this study, we conducted an array-CGH test of 200 patients from the Northeast of Brazil with intellectual disability and/or congenital malformation. Blood samples were collected from the proband and from their parents when possible. DNA.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017769
- DOI:
- 10.4238/gmr.15017769
Intracellular localization and association of MHC class I with porcine invariant chain
Authors: F.Z. Xu S.G. Wu W.Y. Yu
The objective was to investigate the intracellular localization and association of pig major histocompatibility complex (MHC) class I subunits with invariant chain (Ii). Pig MHC class I subunit cDNAs were cloned by RT-PCR and eukaryotic expression plasmids of Ã?± and Ã?²2m were constructed with fusions to red or enhanced green fluorescent protein (pDsRed2-.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.11.17
- DOI:
- 10.4238/2013.March.11.17
HPV31 and HPV33 incidence in cervical samples from women in Recife, Brazil
Authors: M.F.P.T. Baldez da Silva, B.S. Chagas, V. Guimar�£es, L.M.C. Katz,P.M. Felix, P.M. Miranda, A.A. Lima, L.C. Arraes, D.B.G. Martins, J.L. Lima Filho, R.C. Stocco, S. Crovella,7, A.C. Freitas and W. Be�§ak
Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well as disease progression stages and development of vaccines. HPV type prevalence can differ in specific populations in different countries, according to ethnicity. This is the first report o.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr677
- DOI:
- 10.4238/vol8-4gmr677