Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells
Authors: E.��. U�§ar N. Arda A. Aitken
Extracts of mistletoe (Viscum album) are intensively used in complementary medicine, but their mechanisms are not fully understood in most cases, and the effects on metabolism have not been investigated in detail. However, some biologically active natural products are well known to provoke unexpected cellular responses. They reduce overexpression of heat .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.5
- DOI:
- 10.4238/2012.August.24.5
Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase
Authors: Y.-J. Shi K.-K. Huo
Anaphase-promoting complex/cyclosome (APC/C) is a key E3 ubiquitin ligase in cell division, which catalyses ubiquitination of cell-cycle regulators. Studying this complex could reveal important information regarding its application in cancer research and therapy. In this study, 4 synthesized small interfering RNAs (siRNAs) were transfected into HEK293T ce.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.6
- DOI:
- 10.4238/2012.August.24.6
Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine �²-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes
Authors: F.M. Amaral, A.L. Miranda-Vilela, G.S. Lordelo, I.F. Ribeiro, M.B. Daldegan and C.K. Grisolia
High plasma homocysteine (Hcy) âÂ?Â?âÂ?Â?levels may be responsible for vaso-occlusive episodes and may have acquired and/or genetic causes. This cross-sectional study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-β-synthase (CBS; T833C/844ins68, G919A) poly.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019374
- DOI:
- 10.4238/gmr16019374
Monosomic and molecular mapping of adult plant leaf rust resistance genes in the Brazilian wheat cultivar Toropi
Authors: P.R. Da-Silva S.P. Brammer D. Guerra S.C.K. Milach A.L. Barcellos M.I. Baggio
Leaf rust is one of the most destructive diseases affecting wheat worldwide. The most effective way to control it is to use resistant cultivars. Resistance based on slow-rusting adult plant resistance (APR) genes has proven to be the best method for developing cultivars with durable resistance. A source of slow-rusting APR for leaf rust is the Brazilian whea.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.7
- DOI:
- 10.4238/2012.August.24.7
Molecular marker-based genetic diversity analysis of scantly studied Brazilian accessions of a medicinal plant, Morinda citrifolia L. (noni)
Authors: P.N. Bordallo, A.M.R. Monteiro, J.A. Sousa and F.A.S. Arag�£o
Morinda citrifolia L., commonly known as noni, has been used for the treatment of various diseases for over two centuries. It was introduced and widely disseminated in Brazil because of its high market value and ease of adaptation to the soil and climatic conditions of the country. The aim of this study was to estimate the gen.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019531
- DOI:
- 10.4238/gmr16019531
A method for extracting period~10 modulations from DNA sequence correlations applied to the Drosophila melanogaster genome
Authors: J.C.O. Guerra P. Licinio
Nucleosome DNA packaging and positioning within the Drosophila melanogaster genome imposes a weak modulation, with a period of about 10 bp in the genomic composition correlations. We present formalism for extracting such modulations from an irreducible set of six correlation functions calculated along the D. melanogaster genome. These modulations were see.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.8
- DOI:
- 10.4238/2012.August.24.8
Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer
Authors: Y. Shen, Y.F. Ye, L.W. Ruan, L. Bao, M.W. Wu and Y. Zhou
Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019479
- DOI:
- 10.4238/gmr16019479
Genotoxicity of the medicinal plant Maytenus robusta in mammalian cells in vivo
Authors: T.M. Raymundo M. Favilla R. Niero S.F. Andrade E.L. Maistro
Plants belonging to the Celastraceae family have been used in traditional medicine for their analgesic, anti-inflammatory and anti-ulcerogenic properties, among others. Maytenus ilicifolia is the principal species of this family, and is used in the treatment of gastric ulcers. However, owing to its inadequate management in Brazil, the species is becoming ext.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.9
- DOI:
- 10.4238/2012.August.24.9
Spermatogenesis and nucleolar behavior in males of aquatic Heteroptera
Authors: M.M.U. Castanhole
Aspects of spermatogenesis and nucleolar behavior were analyzed in Brachymetra albinerva, Cylindrostethus palmaris, Halobatopsis platensis, Limnogonus aduncus (Gerridae), Martarega sp (Notonectidae), Rhagovelia whitei, and Rhagovelia sp (Veliidae). The testicles are rounded (Veliidae), elongated (Gerridae) or spiral (Notonectidae) and have a transparent m.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3ta019
- DOI:
- 10.4238/vol8-3ta019
Identification of Magnolia wufengensis (Magnoliaceae) cultivars using phenotypic traits, SSR and SRAP markers: insights into breeding and conservation
Authors: L. Wang, A.H. Xiao, L.Y. Ma, F.J. Chen, Z.Y. Sang and J. Duan
A combination of phenotypic characterization and molecular markers may provide reliable information on new plant varieties and elucidate the conservation status of rare species. Five newly developed Magnolia wufengensis cultivars, an endangered plant species endemic to Hubei Province, China, possess more distinctive phenotypes.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019473
- DOI:
- 10.4238/gmr16019473