All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Research Article

Bell’s palsy following growth hormone therapy in a patient with Prader-Willi syndrome: The first report

Received: January 08, 2018
Accepted: January 28, 2018
Published: February 20, 2018
Genet.Mol.Res. 17(1): gmr16039877
DOI: 10.4238/gmr16039877


Prader–Willi syndrome (PWS) is a complex genetic disorder with different manifestations in infancy and childhood including obesity, type 2 diabetes mellitus, mild to moderate intellectual impairment and learning disabilities. In this syndrome, growth hormone therapy improves outcomes. For the first time, here we report a 11-year-old boy with PWS who presented with three episodes of unilateral facial palsy after starting growth hormone therapy.


Prader–Willi Syndrome (PWS) clinical manifestation may present in infancy and child hood with hypotonia, feeding problem, poor growth and development. Affected individuals in childhood develop as more appetite, hyperphagia, obesity, type 2 diabetes mellitus, mild to moderate intellectual impairment, learning disabilities, and some other manifestations.

Genetically, PWS occurred due to genomic imprinting resulting in dysfunctional genes in a specific region of chromosome 15. Briefly, some genes are actively expressed if only a copy is inherited from father, and a paternal chromosome 15 segment is deleted in 70% cases of PWS. Maternal uniparental disomy mainly occurred in the rest of cases (25%), besides some other rare causes for PWS including chromosomal rearrangement (translocation). Although growth hormone therapy has been recommended for PWS to improve the disease outcomes, it has some complications too (Bell J, et al. 2010 and Carrel, et al. 2010).


An 11-year-old boy presented with unilateral facial palsy. The patient was first examined at the age of 4 years because of obesity, weakness, and poor development. At that time, and mainly due to a generalized and prolonged hypotonia, paternal genes on chromosome 15 were evaluated using an MLPA kit (MLPA-ME028-B1; MRC Holland, Amsterdam, The Netherlands) to detect copy number changes and aberrant methylation patterns in the 15q11 locus using an ABI Prism 310 genetic analyser. The evaluation was also carried out in all available family members and an aberrant methylation pattern was found in the region 15q11-q15 in the patient. Therefore, he was diagnosed with Prader Willi syndrome (PWS) either via uniparental disomy or imprinting defects, so a further molecular analysis was recommended to differentiate them using STR analysis and imprinting center sequencing.

Early diagnosis and treatment may improve quality of life in these patients, so we begin human growth hormone (HGH) administration based on Federal Drug Administration (FDA) approval at 9 years old. Linear growth, muscle tone and decreases body fat was improved by HGH replacement but a facial asymmetry were noted with a unilateral peripheral facial nerve deficit without history of trauma or seizure by 6 months after HGH replacement therapy. All other cranial nerves and his blood pressure were normal, and there was no remarkable finding in physical exam.

The laboratory tests including fasting blood glucose and insulin, lipid profiles, complete blood count, serum electrolytes, liver function tests, coagulation tests and the cerebrospinal fluid were in normal ranges. Any intracranial abnormality or evidence of mastoiditis was not obtained in cerebral axial computed tomographic (CT) scan and axial T1- and T2-weighted magnetic resonance imaging (MRI). Growth hormone was discontinued, and the patient was treated with oral hydrocortisone. However, Bell’s palsy was recurred three times more despite GH discontinuation. The results of biochemical and CBC tests are summarized in the Table 1. Genetic testing was approved by the local ethics committees (Guilan University of Medical sciences). With informed consent from the parents and in accordance with the Declaration of Helsinki, genomic DNA was extracted from peripheral blood lymphocytes, and a further genetic assay was performed in the Molecular Genetics Laboratory.

Test Results NL Range
Fasting Blood Sugar (FBS) 90 80-126 mg/dL
Fasting insulin level 12 1.8–24.6 mU/L
Lipid profiles
HDL 50 36–84 mg/dL
LDL 110 64–136 mg/dL
Total Cholesterol 200 125–244 mg/dL
Complete blood count (CBC)
RBC 4.5 4.0–4.9
WBC 8 4.5–10.5
Hemoglobin 12 11.0–13.3
Serum electrolytes
Sodium 137 135–148 mmol/L
Chloride 110 102–112 mmol/L
Potassium 4 3.5–5.8 mmol/L
Phosphorus 4.5 3.2-6.3 mg/dL
Liver function tests
Alkaline Phosphatase 200 115–336
SGOT 35 5-40 U/L
SGPT 36 7 to 56 U/L
Coagulation tests
Prothrombin Time (PT) 13 11–15 sec
Partial Thromboplastin Time (PTT) 48 42–54 sec

Table 1: Patient��?s test results

Discussion and Conculsion

The benefits of HGH treatment in patient with Prader-Willi syndrome are well established including increased linear growth, improved body composition, decreased body fat, increase motor function and psychomotor development (Bell et al., 2010). Side effects of GH were reported in children and adolescents not including Bell’s palsy.

It is the first report of Bell’s palsy in PWS which was improved by the hormone discontinuous. Despite the safety profile of growth hormone treatment, Bell’s palsy association with or secondary to GH therapy has been previously reported in a case as a GH unfavorable side effect or a coincident Clemmons. It may be a co-incidence of Bell’s palsy and PWS, but also it may be a consequence of GH therapy as a side effect too. A predisposition or susceptibility to Bell’s palsy could also be considered in some genetic diseases such as PWS. To confirm this possible tendency, and to better understanding of Bell’s palsy in Prader-Willi syndrome, further studies are recommended.


This work was partly supported by the Intramural Research Program of the National Human Genome Research Institute (NHGRI), NIH.

Conflicts of interest

Authors have no conflict of interest


• It is the first, here we report an 11-year-old boy with PWS and facial (Bell’s) palsy after starting growth hormone therapy.

• A predisposition or susceptibility to Bell’s palsy could also be considered in some genetic diseases such as PWS.

About the Authors

Corresponding Author

Babak Behnam

Medical Genetics Branch, National Human Genome Research Institute (NHGRI), National Institute of Health (NIH), Bethesda, Maryland, USA

Email: /


  • Bell J, Parker K, Swinford R, Hoffman A, et al. (2010). Long-term safety of recombinant human growth hormone in children. The Journal of Clinical Endocrinology & Metabolism. 95(1): 167-177.
  • Carrel AL, Myers SE, Whitman BY, Eickhoff J, et al. (2010). Long-term growth hormone therapy changes the natural history of body composition and motor function in children with Prader-Willi syndrome. The Journal of Clinical Endocrinology & Metabolism. 95(3): 1131-1136. 
  • Toledo Del Castillo B, Kyriakos G, Rold�?¡n Mart�?­n MB (2014). Growth hormone treatment and Bell's palsy: coincidence or consequence? An Pediatr (Barc). 2014 Jan;80(1):61-62.
  • Clemmons DR, Moses AC, McKay MJ, Sommer A, et al. (2000). The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity. J Clin Endocrinol Metab. 85(4):1518-1524. 
  • Koomanaee S, Tabrizi M, Naderi N, Rad AH (2016). Parental Anthropometric Indices and Obesity in Children. Acta Medica Iranica. 54(4):270-275.

Full PDF