Developments in therapeutics are the need of hour for the benefit of mankind and to increase the quality of life. Diabetes mellitus is a non-curable disease affecting a great amount of world’s population. This genetic disorder gets worse with time and ultimately leads to various complications like renal failure, lower limb amputation, heart diseases and blindness. Hydrogels for quite recent time are being used for the drug delivery. The present article is related to the fabrication of psyllium based dermal patches insulin drug delivery system that could release insulin in a sustained and controlled manner. Psyllium, a natural polysaccharide, is a medicinally important dietary fiber and drug delivery system has developed a novel insulin loaded psyllium based hydrogels for glucose lowering. They can be used for the transdermal delivery of insulin as hypodermic administration of insulin is painful, complicated, can also results in allergic reactions and infections. For the sustained and steady release of insulin from fabricated hydrogels were also modified with the addition of graphene oxide nanoparticles.