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MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

Author(s): Y. Yang, J. Qiu, Q. Kan, X.-G. Zhou and X.-Y. Zhou

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA expression profiling studies that compared miRNA expression profiles between BPD lung tissues and normal lung tissues. A vote-counting strategy that considered the total number of studies and time points reporting differential expression was applied.