Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of cancer are the continual debate. Due to the exact cancer causing is still unclear, no matter genetics (endogenous) or environmental pollutant (exogenous) factors. Integrative omics of ovarian cancer in this review has been provided the potential molecular mechanisms, which has better improvement and effectiveness of the diagnosis, prognosis, and treatment for personalized ovarian cancer in clinical practice.