Abstract

Diversity of TNF-�± region in Chinese domestic goats

Tumor necrosis factor-a is a cytokine with a wide range of effects on both lymphoid and non-lymphoid cells. In this study, we identified polymorphisms in major histocompatibility complex class III gene in the 4th exon and the 3' untranslated region of tumor necrosis factor-a to evaluate the immunogenetic diversity of Chinese south indigenous goat. Three single-nucleotide polymorphisms were identified and showed similar frequencies in different except MI loci. These data suggest that the high immunodiversity of the tumor necrosis factor-a region within these breeds can be used for strengthening variety improvement and promoting animal husbandry development in Chinese indigenous goats.