Abstract

Biophysical and biochemical mechanisms disturbance of cellular genome leading to transmutation benign neoplasm into cancer

It was considered processes transmutation of genome mechanism from the point of view of thermodynamics, biophysics, and biochemistry. Just it was explained mechanisms maintenance stability Internal Energy of Stationary State an able-bodied organism according first law of thermodynamics. Besides it was considered some negative influences on an organism of solar radiation causing germination viruses. Hence it was described mechanisms normal development of an organism reflecting activity of cellular genomes via generating cellular divisions. The links between genomic mechanisms and mechanisms maintenance stability Internal Energy of an organism and cells of an organism exert activity stem cells which induce cells types division in healthy tissues. The local violation these links due to viral affection causes local tissue transitions normal genomic cycle into genomic cycle of benign neoplasm, i.e., the transition of genomic link due to viral affection of cellular genomic link leading to forming benign neoplasm. The mechanism of these transformations in cellular genome was described from point of views of thermodynamics, biophysics, and biochemistry. Also, it was elucidated the cause that genomic mechanism of benign neoplasm don’t break Stationary State of an organism. Furthermore, it was described the viral affecting genomic link of cells in benign neoplasm causing mechanism transmutation benign neoplasm into cancer with forming Warburg effect mechanism. The forming cancer metabolism creates Quasi-Stationary State of cancer disease organism

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