The Bayesian network (BN) is a knowledge representation form, which has been proven to be valuable in the gene regulatory network reconstruction because of its capability of capturing causal relationships between genes. Learning BN structures from a database is a nondeterministic polynomial time (NP)-hard problem that remains one of the most exciting challenges in machine learning. Several heuristic searching techniques have been used to find better network structures. Among these algorithms, the classical K2 algorithm is the most successful. Nonetheless, the performance of the K2 algorithm is greatly affected by a prior ordering of input nodes.
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