All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Human Genetics   Research Article

Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer

Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy

Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

Haplotypes and polymorphism in the CCR5 gene in sickle cell disease

Authors: A.F. Nascimento, J.S. Oliveira, J.C. Silva Junior and A.A.L. Barbosa

Sickle cell disease shows several clinical manifestations in distinct levels of severity. This heterogeneity is due to the haplotype variability associated with the HbS gene, levels of fetal hemoglobin and environmental conditions, which modify the disease expression. Science community believes that the presence of a polymorph.. Read More»

Genet. Mol. Res. 16(2):
gmr16029675
DOI:
10.4238/gmr16029675
Animal Genetics   Research Article

Cloning and expression analysis of the 37-kDa laminin receptor precursor gene from Hyriopsis cumingii

Authors: X.Z. Chang1, J.L. Li1,2, Z.Y. Bai1 and X.L. Li1

Hyriopsis cumingii is an economically important freshwater pearl mussel with high pearl quality that is endemic in China. Investigation of genes relevant to shell formation is important for increased pearl output. The substances that form mollusk shells are secreted by epithelial cells in the mantle, the proliferation of which influences secretion ability.. Read More»

Genet. Mol. Res. 13(4):
2013.December.2.10
DOI:
10.4238/2013.December.2.10
Medical Genetics   Research Article

Homocysteine induces blood vessel global hypomethylation mediated by LOX-1

Authors: X.L. Yang, J. Tian, Y. Liang, C.J. Ma, A.N. Yang, J. Wang, S.C. Ma, Y. Cheng, X. Hua and Y.D. Jiang

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change i.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.2
DOI:
http://dx.doi.org/10.4238/2014.May.16.2
Animal Genetics   Research Article

Olfactory mucosal microstructural changes in a rat model of acute rhinosinusitis with dysosmia

Authors: J. Ye, J.P. He and Z.J. Liu

This study aimed to examine olfactory mucosal changes in a rat model of acute rhinosinusitis and to determine how acute rhinosinusitis induces dysosmia. Total 100 rats were divided into the experimental (N = 80) and control (N = 20) groups. An acute rhinosinusitis model was established in the experimental rats. From the experi.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.16.11
DOI:
http://dx.doi.org/10.4238/2014.May.16.11
Human Genetics   Research Article

Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium

Authors: A.W. Le, Z.H. Wang, R. Yuan, L.L. Shan, T.H. Xiao, R. Zhuo, Y. Shen

The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (cont.. Read More»

Genet. Mol. Res. 12(4):
2013.November.26.7
DOI:
10.4238/2013.November.26.7
Human Genetics   Research Article

Correlation of SPECT imaging, biochemical parameters and mutation with systolic dysfunction

Authors: D. Alenizi, N.A. Kizilbash, O. Gill, A. Abukanna, S. Malik, A. Badawy

We investigated systolic dysfunction by the use of biochemical laboratory tests and perfusion single-photon emission computed tomography imaging in 32 Pakistani subjects exhibiting symptoms of this disorder. To investigate underlying genetic causes, such as familial hypercholesterolemia, DNA samples from these subjects were sc.. Read More»

Genet. Mol. Res. 12(4):
2013.November.26.6
DOI:
10.4238/2013.November.26.6
Animal Genetics   Research Article

Identification of spliced mRNA isoforms of retinoid X receptor (RXR) in the Oriental freshwater prawn Macrobrachium nipponense

Authors: Z. Li, W.Q. Wang, E.F. Zhang and G.F. Qiu

Retinoid X receptors (RXR) are members of the nuclear receptor family that are conserved from invertebrates to vertebrates, and they play an essential role in regulating reproductive maturation, molting, and embryo development. In this study, fi ve RXR isoforms, named RXRL2 (L, long form), RXRL3, RXRS1 (S, short form), RXRS2, .. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.23.2
DOI:
http://dx.doi.org/10.4238/2014.May.23.2
Bioinformatics   Research Article

Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature

Authors: Y. Yang, H. Huang,W. Wang, L. Yang, L.L. Xie and W. Huang

The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyp.. Read More»

Genet. Mol. Res. 12(4):
2013.October.18.14
DOI:
10.4238/2013.October.18.14
Human Genetics   Research Article

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Authors: L.Wang, Z.T. Wang, J.J. Hu, R. Fan, J. Zhou and J. Zhong

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inco.. Read More»

Genet. Mol. Res. 13(2):
2014.April.8.2
DOI:
10.4238/2014.April.8.2